This book contains a series of review chapters from the world's leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.Contents:The HSV-2 Gene ICP10PK: A Future in the Therapy of Neurodegeneration (Laure Aurelian)What Doesn't Belong and Why: A Saga of Latency Associated Proteins Elaborated by Varicella Zoster Virus (Matthew S Walters, Christos A Kyratsous, Christina L Stallings, Octavian Lungu and Saul J Silverstein)Selected Aspects of Herpesvirus DNA Replication, Cleavage/Packaging and the Development and Use of Viral Amplicon Vectors (Niza Frenkel, Ronen Borenstein and Haim Zeigerman)Chromatin Structure of the Herpes Simplex Virus 1 Genome During Lytic and Latent Infection (Anna R Cliffe and David M Knipe)The Proboscivirus Genus: Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesviruses (Jian-Chao Zong, Erin Latimer, Sarah Y Heaggans, Laura K Richman and Gary S Hayward)A Molecular Mass Gradient is the Key Parameter of the Genetic Code Organization (Felix Filatov)From Latent Herpes Viruses to Persistent Bornavirus Dedicated to Bernard Roizman (Hanns Ludwig and Liv Bode)Virus Infections and Development of Cervical Cancer (Bodil Norrild)Cytomegalovirus Control of Cell Death Pathways (A Louise McCormick and Edward S Mocarski)Herpesviruses as Oncolytic Agents (Gabriella Campadelli-Fiume, Laura Menotti, Grace Zhou, Carla De Giovanni, Patrizia Nanni and Pier Luigi LolliniRole of Cellular MicroRNAs During Human Cytomegalovirus Infection (Kavitha Dhuruvasan, Geetha Sivasubramanian and Philip E Pellett)Burkitt's Lymphoma and EBV — The Role of LMP2A (Kathryn T Bieging and Richard Longnecker)Replicative Herpes Simplex Virus Vectors for Therapy of Autoimmune Central Nervous System Disease (Veijo Hukkanen, Michaela Nygårdas and Eeva Broberg)The Herpes Simplex Virus DNA Packaging Machine (Joel D Baines)Post-Transcriptional Gene Regulation: Role of the Polypyrimidine Tract-Binding Protein (PTB) and Associated Factors (Maria Grazia Romanelli and Erica Diani)Nucleotidylation to Oncoapoptosis (John A Blaho, Martine Aubert, Kathy Bae, Brooke Baker, Jenny Balderama, Renee Baranin, Monica Bhanot, Amanda Blouin, Robert N Bowles, Isabella Chi, F Natalie W Chirimuuta, Christopher R Cotter, Elisabeth Gennis, Laura Gillim, Margot L Goodkin, Kristin Ingvarsdottir, Andrea E Ireland, Leah Kang, Surinder Kaul, Anna Kotsakis, Rachel M Kraft, Renzo C Lambardozzi, Maria R Lopez, Fatima Manzoor, Kerryn A Mortimer, Elise R Morton, Marie L Nguyen, Jennifer M O'Toole, Jason Paragas, Kristen C Pena, Lisa E Pomeranz, Deleen Sabbah, Christine M Sanfilippo, Louis R Serico, Elisabeth F M Schlegel, Chintal Shah, Cecylia Stabrawa, Dennis Vega, Sandra Winstersteller, Jamie C Yedowitz and C Susan Zong)Geographic Distribution and High Frequency of Herpes Simplex Virus Type 1 BgKL Variant in Orolabial/Cutaneous Infections: The HSV-1 Variant Dispersion-Replacement Model (Kazuo Yanagi)Virucidal Ability of Arginine and Its Possible Application as an Antiherpetic Agent (Keiko Ikeda, Hisashi Yamasaki, Sawako Minami, Takeshi Naito, Hiroshi Irie, Tsutomu Arakawa and A Hajime Koyama)Genetic Analyses of Human Cytomegalovirus Towne Strain by Deletion Mutagenesis (Edward Yang, Paul J Rider and Fenyong Liu)Angiogenic and Oncogenic Alterations of Endothelial Cells by KSHV (Valerie A Morris, Terri Dimaio, Almira S Punjabi and Michael Lagunoff)Decoding Neural Circuitry with Optogenetics: Applications for Epilepsy (Philip Barish, Svetlana Kantorovich, Paul Carney and William Ogle)From Psychosocial Stress to Herpes Simplex Infection: A Sequence of Coordinated Events Regulated in a Cascade Fashion (Rosario Leopardi and Alessandro Bartolomucci)Herpes Simplex Viruses and Interferon Responses (Yijie Ma and Bin He)Herpes Virus Genes and Gene Regulation: Insights from Systems Biology (Joanne Trgovcich)Viral Manipulation of Cellular Metabolic Signal Transduction Pathways (Joshua Munger)How Herpesviruses and Cells Tussle to Control Autophagy (Audrey Esclatine)Epilogue — Kovler Poems (Susanna Rudofsky)Readership: Researchers and medical professionals who are working with or need to know more about herpesviruses.
