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97. Ibid.

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101. Centers for Disease Control and Prevention, “Arthritis National Statistics”, February 2018, https://www.cdc.gov/arthritis/data_statistics/national– statistics.html.

102. David E. Trentham, Roselynn Dynesius Trentham, E. John Orav, et al., “Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis”, Science 261 (1993): 1727–1730.

103. Kenji Sato, “How Collagen Hydrolysate Works on Your Skin and Joints”, Inform 29 (2018).

104. Ibid.

105. Ibid.

106. O. Bruyere, B. Zegels, L. Leonori, et al., “Eff ect of Collagen Hydrolysate in Articular Pain: A 6-Month Randomized, Double– Blind, Placebo-Controlled Study”, Complementary Th erapies in Medicine 20 (2012): 124–130.

107. P. Benito– Ruiz, M. M. Camacho– Zambrano, J. N. Carrillo– Arcentales, et al., “A Randomized Controlled Trial on the Effi cacy and Safety of a Food Ingredient, Collagen Hydrolysate, for Improving Joint Discomfort”, International Journal of Food Sciences and Nutrition 60 (2009): 99–113.

108. A. Czajka, E. M. Kania, L. Genovese, et al., “Daily Oral Supplementation with Collagen Peptides Combined with Vitamins and Other Bioactive Compounds Improves Skin Elasticity and Has a Benefi cial Eff ect on Joint and General Wellbeing”, Nutrition Research 57 (2018): 97–108.

109. J. M. Garcia– Coronado, L. Martinez– Olivera, R. E. Elizondo– Omana, et al., “Effect of Collagen Supplementation on Osteoarthritis Symptoms: A Meta-Analysis of Randomized Placebo– Controlled Trials”, International Orthopaedics 43 (2019): 531–538.

110. Qurratul-Ain Dar, Eric M. Schott, Sarah E. Catherine, et al., “Daily Oral Consumption of Hydrolyzed Type I Collagen Is Chondroprotec-tive and Anti-infl ammatory in Murine Posttraumatic Osteoarthritis”, PLOS One 12 (2017).

111. W. Wei, L. L. Zhang, J. H. Xu, et al., “A Multicenter, Double– Blind, Randomized, Controlled Phase III Clinical Trial of Chicken Type II Collagen in Rheumatoid Arthritis”, Arthritis Research & Th erapy 11 (2009).

112. Ronald J. Maughan, Louise M. Burke, Jiri Dvorak, et al., “IOC Consensus Statement: Dietary Supplements and the High– Performance Athlete”, International Journal of Sport Nutrition and Exercise Metabolism 28 (2018): 104–125.

113. Kristine L. Clark, Wayne Sebastianelli, Klaus R. Flechsenhar, et al., “24 Week Study on the Use of Collagen Hydrolysate as a Dietary Supplement in Athletes with Activity– Related Joint Pain”, Current Medical Research and Opinion 24 (2008): 1485–1496.

114. Ibid.

115. Stephan F. E. Praet, Craig R. Purdam, Marijke Welvaert, et al., “Oral Supplementation of Specifi c Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients”, Nutrients 11 (2019).

116. Gregory Shaw, Ann Lee– Barthel, Megan L. R. Ross, et al., “Vitamin C-Enriched Gelatin Supplementation before Intermittent Activity Augments Collagen Synthesis”, American Journal of Clinical Nutrition 105 (2017): 136–143.

117. Linda Rath, “CBD Oil: Should You Try It for Arthritis Symptoms?” Arthritis Foundation, https://www.arthritis.org/living-with-arthritis/treatments/natural/supplements– herbs/cannabidiol-oil.php.

118. Ibid.

119. Ibid.

120. “One in Four Americans Develop Insomnia Each Year”, June 8, 2018, https://penntoday.upenn.edu/news/one-four-americans-develops-insomnia-each-year.

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122. Kentara Inagawa, Takenori Hiraoka, Tohru Kohda, et al., “Subjective Effects of Glycine Ingestion before Bedtime on Sleep Quality”, Sleep and Biological Rhythms 4 (2006): 75–77.

123. Makoto Bannai and Nobuhiro Kawai, “New Th erapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep”, Journal of Pharmacological Sciences 118 (2012): 145–148.

124. “Facts & Statistics”, Anxiety and Depression Association of America, https://adaa.org/about-adaa/press-room/facts– statistics.

125. Makato Bannai, Nobuhiro Kawai, Kenji Nagao, et al., “Oral Administration of Glycine Increases Extracellular Serotonin but Not Dopamine in the Prefrontal Cortex of Rats”, Psychiatry and Clinical Neurosciences 65 (2011): 142–149.

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128. Mohammed El Hafi di, Israel Perez, Jose Zamora, et al., “Glycine Intake Decreases Plasma Free Fatty Acids, Adipose Cell Size, and Blood Pressure in Sucrose– Fed Rats”, American Journal of Physiology – Regulatory, Integrative and Comparative Physiology 287 (2004): R13B7–R1393.

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131. Denise Zdzieblik, Steff en Oesser, Manfred W. Baumstark, et al., “Collagen Peptide Supplementation in Combination with Resistance Training Improves Body Composition and Increases Muscle Strength in Elderly Sarcopenic Men: A Randomised Controlled Trial”, British Journal of Nutrition 114 (2015): 1237–1245.

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