Brickman AM, Schupf N, Manly JJ, et al. Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Arch Neurol. 2008;65(8):1053–1061. doi: 10.1001/archneur.65.8.1053
Crane PK, Walker R, Hubbard RA, et al. Glucose levels and risk of dementia. N Engl J Med. 2013;369(6):540–548. doi: 10.1056/NEJMoa1215740. Erratum in: N Engl J Med. 2013 Oct 10;369(15):1476.
Caunca MR, Simonetto M, Cheung YK, et al. Diastolic blood pressure is associated with regional white matter lesion load: the Northern Manhattan Study. Stroke. 2020;51(2):372–378. doi: 10.1161/STROKEAHA.119.025139. Epub 2020 Jan 8.
DeCarli C. Clinically asymptomatic vascular brain injury: a potent cause of cognitive impairment among older individuals. J Alzheimers Dis. 2013;33 Suppl 1(01):S417–S426. doi: 10.3233/JAD-2012-129004
Denver P, McClean PL. Distinguishing normal brain aging from the development of Alzheimer’s disease: inflammation, insulin signaling and cognition. Neural Regen Res. 2018;13(10):1719–1730. doi: 10.4103/1673-5374.238608
Flint AC, Conell C, Ren X, et al. Effect of systolic and diastolic blood pressure on cardiovascular outcomes. N Engl J Med. 2019;381(3):243–251. doi: 10.1056/NEJM oa1803180
Gorelick PB, Nyenhuis D. Stroke and cognitive decline. J Am Med Assoc. 2015;314(1):29–30. doi: 10.1001/jama.2015.7149
Goss AM, Gower B, Soleymani T, et al. Effects of weight loss during a very low carbohydrate diet on specific adipose tissue depots and insulin sensitivity in older adults with obesity: a randomized clinical trial. Nutr Metab. 2020;7(64) doi: 10.1186/s12986-020-00481-9
Graff-Radford J. Vascular cognitive impairment. Continuum. 2019;25(1):147–164. doi: 10.1212/CON.0000000000000684
Grinberg LT, Thal DR. Vascular pathology in the aged human brain. Acta Neuropatholog. 2010;119(3):277–290. doi: 10.1007/s00401-010-0652-7. Epub 2010 Feb 14.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139(25):e1082–e1143. doi: 10.1161/CIR.0000000000000625. Epub 2018 Nov 10. Erratum in: Circulation. 2019 Jun 18;139(25):e1182–e1186. 230 For Further Reading
Hainsworth AH. White matter lesions in cerebral small vessel disease: Underperfusion or leaky vessels? Neurology. 2019;92(15):687–688. doi: 10.1212/WNL.0000000000007258. Epub 2019 Mar 13.
Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5–6):231–237. doi: 10.1242/dmm.001180
Hughes D, Judge C, Murphy R, et al. Association of blood pressure lowering with incident dementia or cognitive impairment: a systematic review and meta-analysis. J Am Med Assoc. 2020;323(19):1934–1944. doi: 10.1001 /jama.2020.4249
Iadecola C. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropatholog. 2010;120(3):287–296. doi: 10.1007/s00401-010-0718-6. Epub 2010 Jul 11.
Jellinger KA. Pathology and pathogenesis of vascular cognitive impairment-a critical update. Front Aging Neurosci. 2013;5:17. doi: 10.3389/fnagi.2013.00017
Kalaria RN, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochimica et Biophysica Acta. 2016;1862(5):915–925. doi: 10.1016/j.bbadis.2016.01.015. Epub 2016 Jan 22.
Koike MA, Green KN, Blurton-Jones M, Laferla FM. Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Am J Pathol. 2010;177(1):300–310. doi: 10.2353/ajpath.2010.090750. Epub 2010 May 14.
Kuehn BM. In Alzheimer research, glucose metabolism moves to center stage. J Am Med Assoc. 2020;323(4):297–299. doi: 10.1001/jama.2019.20939
Lane CA, Barnes J, Nicholas JM, et al. Associations between vascular risk across adulthood and brain pathology in late life: evidence from a British birth cohort. JAMA Neurol. 2020;77(2):175–183. doi: 10.1001/jamaneurol.2019.3774.
Lee ATC, Richards M, Chan WC, Chiu HFK, Lee RSY, Lam LCW. Higher dementia incidence in older adults with type 2 diabetes and large reduction in HbA1c. Age Ageing. 2019;48(6):838–844. doi: 10.1093/ageing/afz108
Levine DA, Galecki AT, Langa KM, et al. Trajectory of cognitive decline after incident stroke. J Am Med Assoc. 2015;314(1):41–51. doi: 10.1001/jama.2015.6968
Lo JW, Crawford JD, Samaras K, et al. Association of prediabetes and type 2 diabetes with cognitive function after stroke: a STROKOG collaboration study. Stroke. 2020;51(6):1640–1646. doi: 10.1161/STROKEAHA.119.028428. Epub 2020 May 14.
McAllister TW. Neurobehavioral sequelae of traumatic brain injury: evaluation For Further Reading 231 and management. World Psychiatry. 2008;7(1):3–10. doi: 10.1002/j.2051–5545.2008.tb00139.x
McMillan JM, Mele BS, Hogan DB, Leung AA. Impact of pharmacological treatment of diabetes mellitus on dementia risk: systematic review and metaanalysis. BMJ Open Diabetes Res Care. 2018;6(1):e000563. doi: 10.1136/bmjdrc-2018-000563
Meusel LA-C, Greenwood CE, Maione A, Tchistiakova E, MacIntosh BJ, Anderson ND. Cardiovascular risk and encoding-related hippocampal connectivity in older adults. BMC Neurosci. 2019;20,37. doi: 10.1186/s12868-019-0518-4
Qiu L, Ng G, Tan EK, Liao P, Kandiah N, Zeng L. Chronic cerebral hypoperfusion enhances tau hyperphosphorylation and reduces autophagy in Alzheimer’s disease mice. Sci Rep. 2016 Apr 6;6:23964. doi: 10.1038/srep23964
Román GC. Vascular dementia may be the most common form of dementia in the elderly. J Neurolog Sci. 2002;203–204:7–10. doi: 10.1016/s0022-510x(02)00252-6
Sila CA. Cognitive impairment in chronic heart failure. Cleve Clin J Med. 2007;74 Suppl 1:S132–S137. doi: 10.3949/ccjm.74.suppl_1.s132
Smith EE, O’Donnell M, Dagenais G, et al. Early cerebral small vessel disease and brain volume, cognition, and gait. Ann Neurol. 2015;77:251–261. doi: 10.1002/ana.24320
Sperling RA, Donohue MC, Raman R, et al. Association of factors with elevated amyloid burden in clinically normal older individuals. JAMA Neurol. 2020;77(6):735–745. doi: 10.1001/jamaneurol.2020.0387
Tatemichi TK, Paik M, Bagiella E, et al. Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study. Neurology. 1994;44(10):1885–1891. doi: 10.1212/wnl.44.10.1885
Wium-Andersen IK, Osler M, Jørgensen MB, Rungby J, Wium-Andersen MK. Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case-control study. Eur J Endocrinol. 2019;181(5):499–507. doi: 10.1530/EJE-19-0259
Wolters FJ, Ikram MA. Epidemiology of vascular dementia. Arterioscler Thromb Vasc Biol. 2019;39(8):1542–1549. doi: 10.1161/ATVBAHA.119.311908. Epub 2019 Jul 11.
Xie W, Zheng F, Yan L, Zhong B. Cognitive decline before and after incident coronary events. J Am Coll Cardiol. 2019;73(24):3041–3050. doi: 10.1016/ j.jacc.2019.04.019. Erratum in: J Am Coll Cardiol. 2019 Sep 3;74(9):1274.
Yang T, Sun Y, Lu Z, Leak RK, Zhang F. The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev. 2017;34:15–29. doi: 10.1016/j.arr.2016.09.007. Epub 2016 Sep 28.
Zhang J, Chen C, Hua S, et al. An updated meta-analysis of cohort studies: diabetes and risk of Alzheimer’s disease. Diabetes Res Clin Pract. 2017;124:41–47. doi: 10.1016/j.diabres.2016.10.024. Epub 2016 Nov 9.
Zuccalà G, Cattel C, Manes-Gravina E, Di Niro MG, Cocchi A, Bernabei R. Left ventricular dysfunction: a clue to cognitive impairment in older patients with heart failure. J Neurol Neurosurg Psychiatry. 1997;63(4):509–512. doi: 10.1136/jnnp.63.4.509
Chapter 5. Lifestyle Factors of Smoking, Diet, and Exercise
Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. Walking and dementia in physically capable elderly men. J Am Med Assoc. 2004;292(12):1447–1453. doi: 10.1001/jama.292.12.1447