Peter Piot, founding executive director of the Joint United Nations Programme on HIV/AIDS (UNAIDS), reports on the influence of civil society in international relations and traditional partisan divides. AIDS thrust health into national and international politics where, he argues, it rightly belongs. The global reaction to AIDS over the past decade is the positive result of this partnership, showing what can be acheved when science, politics, and policy converge on the ground. Piot describes funding mechanisms for AIDS, the first international declarations, the response of the UN system, the establishment of UNAIDS, the response of high income countries to AIDS, The Global Fund and PEPFAR as game-changers, and lessons for other health problems.