Two female teachers are camping in the wilderness at the junction of Wayah Mountain and the Appalachian Trail. One is murdered and the other disappears without a trace. Through a series of discoveries, the mystery begins to unravel. With the help of the husband of the murdered woman, lawmen chase the case for two years, after the serial killer whom they must extract from his cliff hideaway in the Nantahala National Forest. Based on actual events, 'The Owl Knows' is a story of mystery, friendship, and love amidst the background of the Appalachian Mountains.