This volume presents an overview of recent developments in systems biology and their applications in cancer-related research. The ongoing advances in our understanding of genomics and proteomics, coupled with the development of new and more robust tools, have led to an emphasis on analyzing biological systems at multiple levels. Thus, there is a need to integrate different types of data into a comprehensive “systems” view.Written by active researchers in the emerging areas, this book gives senior undergraduate students, graduate students and new researchers an idea of where the frontiers of systems biology are and an opportunity to learn high-throughput techniques in use. One of the particular emphases of the book is to elucidate the molecular mechanisms in cancer. The discovery of biomarkers and anti-cancer drugs using systems biology approach is also extensively discussed.Contents:Gene/Protein Networks and Pathways:Introduction to Systems Biology (Hsueh-Fen Juan)Gene Network Construction for Molecular Regulation (Hsueh-Fen Juan and Hsuan-Cheng Huang)MicroRNA Regulation in Cellular Networks (Hsueh-Fen Juan and Hsuan-Cheng Huang)Disease Modules in Protein–Protein Interaction Networks (Hsueh-Fen Juan and Hsuan-Cheng Huang)Biomolecular Pathway Modeling (Feng-Sheng Wang and Wu-Hsiung Wu)High-Throughput Omics Data and Analysis:ChIP-Seq Analytics: Methods and Systems to Improve ChIP-Seq Peak Identification (Stuart Brown, D Frank Hsu, Christina Schweikert and Zuojian Tang)Discovery of Transcription Factor Binding Sites and Its Applications in Cancer Study (Chien-Yu Chen)Cancer Epigenomics (Jer-Wei Chang and Yi-Ching Wang)Cancer Phosphoproteomics: Tools and Emerging Applications for Mining the Phosphoproteome in Cancer Biology(Hsin-Yi Wu, Chuan-Chih Hsu, Yi-Ting Wang, Chia-Feng Tsai, Yu-Ni Sun and Yu-Ju Chen)Predicting MicroRNAs (Arthur Chun-Chieh Shih and Tsunglin Liu)MicroRNA Research in Cancer Biology: Databases and Tools (Hsien-Da Huang)Applications for Biomarkers and Drug Discovery:The Application of the Next-Generation Sequencing Technologies in Cancer Research (Lihua Cheng, Hong Xu and Biaoyang Lin)Membrane Proteomics for the Opportunity of Cancer Biomarker and Drug Target Discovery (Chia-Li Han, Chih-Wei Chien, Pei-Mien Chen, I-Hsuan Chen and Yu-Ju Chen)Structure-Based Systems Biology and Drug Design in Cancer Research (Chun-Hua Hsu)Discovering Drug Targets for Cancer Therapy (Tsui-Chin Huang, Hsin-Yi Chang and Hsueh-Fen Juan)Readership: This book is an essential source of reference for medical doctors, oncologists, chemists, genome biologists and computational biologists. It is also suitable for senior undergraduate, graduate students and researchers who are interested in systems biology and cancer research.