Providing a catalogue of suggested solutions for different categories of issues, this book offers a balanced overview and methodological examples for the practical implementation of the CRA. It considers CRA in the USA, Europe and Germany, using case studies to analyze and exemplify the decision-making processes and challenges involved. The authors then go on to look at the practical lessons learned from these case studies, together with an in-depth discussion of the underlying scientific hypotheses. Sound scientific knowledge for everyone who makes decisions, whether government ministers, regulators, or company directors.