The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career?Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area.Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review — both by experts in the field and a “jobbing” general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information.Contents:Neurogenetics — Single Gene DisordersNeurogenetics II: Complex DisordersFunctional Genomics and Proteomics: Application in NeurosciencesMitochondriaNanotechnology for Neuronal Ion ChannelsMolecular and Cellular Pathways of Neurodegeneration in Motor Neurone DiseaseNeurodegenerative Disorders: Parkinson's Disease and Huntington's DiseaseMolecular Pathogenesis of NeuroinflammationNeurovirologyMolecular Neurology of Prion DiseaseMonitoring and Interpretation of Intracranial PressureCerebral Perfusion and StrokeA Review of Structural Magnetic Resonance NeuroimagingApplications of Positron Emission Tomography (PET) in NeurologyFunctional Magnetic Resonance ImagingHow to Spot Bias and Other Potential Problems in Randomised Controlled TrialsReadership: Neurologists, trainees/interns in neurology and related disciplines, neurobiologists.