This book serves as a supplement to The Pyrazines, Volume 41 of the Chemistry of Heterocyclic Compounds series. It covers the literature published between 1979 and 2000, and together with Volume 41 provides a complete, up-to-date reference for heterocyclic chemists. It emphasizes practical approaches to pyrazine chemistry, offers a full appendix of all simple pyrazines up to 2000, and features detailed coverage of the following topics: Systematic descriptions of all primary synthetic routes to pyrazines Other preparative routes to alkylpyrazines and their reactions Halogenopyrazines and their synthetic uses Oxypyrazines and trivial names for pharmaceutical or agrochemical pyrazines Thiopyrazines Amino-, nitro-, and other similar pyrazines and their reactions Pyrazinecarboxylic acids and their derivatives The supplement features extensive cross-references to the original volume and uses chemical nomenclature as per current IUPAC recommendations