Scientific Freedom outlines what needs to be done to restore the freedom that can transform scientific understanding. The author defines Transformative Research (Venture Research) and explains how an initiative might be designed and implemented; discusses the revolutionary concept of low-risk, high-reward research; explains the wider significance of instability, and introduces the formidable Damocles Zone; explores threats to the university as an institution; and describes how a Transformative Research initiative might work in practice.