Complete coverage of chemical literature on simple pyrazines recorded in Beilstein to 1929, and Chemical Abstracts through 1978 (volume 89), together with selected references to 1980. Describes their history, occurrence, biological activity and uses, and nomenclature. Classified primary syntheses of pyrazines according to the starting materials employed. Treats primary syntheses of pyrazine N-oxides. Details syntheses, properties and reactions of alkyl, halogeno, hydroxy, mercapto, amino and carboxy pyrazines and their derivative and related compounds. Extensive table lists known simple pyrazines, physical data such as melting points and boiling points, and references.