This issue on Hypoventilation Syndrome covers a variety of topics such as Sleep hypoventilation: Diagnostic considerations and technological limitations,Pathophysiology of hypoventilation during sleep,Advances in PAP treatment modalities for hypoventilation syndromes,Scoring abnormal respiratory events on polysomnography during noninvasive ventilation,OHS Epidemiology and diagnosis,OHS outcomes,Non-PAP treatment modalities in OHS, Pulmonary overlap syndromes,Noninvasive ventilation during sleep in stable COPD and more!