This issue of Primary Care: Clinics in Office Practice, edited by Mack T. Ruffin IV, MD, MPH and Cameron G. Shultz PhD, MSW, is devoted to Preventive Medicine. Articles in this issue include Risk Assessment Approach Screening; Substance Use and Tobacco Screening; Sexually Transmitted Infections; Planned Pregnancy; Violence Screening; Breast Cancer Screening; Lung Cancer Screening; Colorectal Cancer Screening; Prostate Cancer Screening; Heart Disease Screening; Screening for Depression; and Use of Genetic Markers.