This monograph summarizes research conducted at Moscow Institute of Steel and Alloy during many decades in part together with Alcoa Inc. The research covered areas of the structure, properties, thermal resistance, corrosion and fatigue of aluminum alloys in industrial manufacturing.* Emphasis on interconnection among phase equilibria, thermodynamics and microstructure of alloys;* Systematic overview of all phase diagrams with Al that are important for the development of casting aluminium alloys* Diagrams ("processing windows") of important technological properties such as castability, molten metal fluidity, tendency to hot pre-solidification cracking, porosity* Mathematical models for alloy mechanical properties facilitating the down-selection of best prospect candidates for new alloy development * New principles of design of eutectic casting aluminium alloys* Examples of successful novel casting alloy development, including alloys for high-strength applications, alloys with transition metals, and novel alloys utilizing aluminium scrap